Biology student WSSU
Evaluation of biological literature
A human germline modification scale
The author addresses the guidelines for the function of gene modification techniques. Targeting towards a germline stand point, the article compares the germline gene modifications to the rate of medical development. Furthermore, acts of durability in different ways of gene editing are emphasized. Utilizing mouse models to demonstrate the accuracy of gene modification and its response. This information is relevant to my paper because it expresses the factors of gene editing being permissible to the human body.
Adams H. A Human Germline Modification Scale. Journal of Law, Medicine & Ethics. 2004; 32: 164-173.
CRISPR/Cas9 Genome Editing- New and Old Ethical Issues Arising from a Revolutionary Technology
Embodied upon biotechnology, factors of the new gene editing technology, CRISPR/ Cas9 is promoted. An experiment indicating the modification of human embryos is correlated through out the article. The authors express a clear clinical performance of gene editing, articulating synthetic biology. Delivering the process of how the DNA is clinically edited on human embryos. This information is valuable to my paper because it gives input on how the gene is edited. Also, the clinical trials performed on human embryos and animals as well.
Baumann M. CRISPR/Cas9 Genome Editing- New and Old Ethical Issues Arising from a Revolutionary Technology. Nanoethics. 2016; 10: 139-159.
Launching a Revolution in Medicine
This resource highlights the act of gene therapy in the revolution of genetics and genomics. The article discusses the applications used to directly read a genome to identify genes. Through documented data collected concerning chromosomes and genes, the researchers sought to trace the inheritance of major diseases. This resource supports my review paper because it articulates the editing of certain genes and their relation to fatal diseases.
Lander E. Genomics: Launching a Revolution in Medicine. Whitehead Policy Symposium. 2000; 3-14.
Production of Immunodeficient Rabbits by Multiplex Embryo Transfer and Multiplex Gene Targeting
This resource examines clinical trials of multiplex embryo transfer casted upon immunodeficient rabbits. Demonstrating efficient gene targeting on mutated genes, the article delivers information surrounding designer animals. Explaining the lines for choosing a rabbit model experiment, the resource focuses on a pool of genes for embryo transfer. Also, the author incorporates the use of CRISPR upon genetically manipulated animals. The objectives surrounding germline transmission of single- gene mutant founders are critical to my paper.
Song J, Yang D, Ruan J, Zhang J, Chen Y, Xu J. Production of Immunodeficient Rabbits by Multiplex Embryo Transfer and Multiplex Gene Targeting. Nature- Scientific Reports. 2017; 1-7.
Three Parent Baby
Representing molecular and cell biology, the article expresses mitochondrial replacement therapy. Exclaiming two different approaches to repairing mutated mtDNA to eliminate significant inheritable diseases. Pronuclear transport and spindle- chromosomal complex transfer are interpreted throughout this study. This resource supports my review paper because it expresses the gene editing in collected eukaryotic cells.
Tai S. Mitochondrial Replacement Therapy and the “Three Parent Baby”. Studies by Undergraduate Researchers at Guelph. 2016; Vol. 9, No. 1: 48-54.