Biology student WSSU
Biological Seminars
Lack of physical inactivity leading to insulin resistance
Frank Booth
Frank Booth depicted his research based upon a conversational statement made by Roger Bannister. His words declared were “Use my argument that physical inactivity may prevent you from seeing your grandchildren”. Directing his research in space, Booth utilized a ground base model to explore the effects of gravity and bone loss, regarding skeletal muscle. Stemming from Bannister’s quote, Booth also studied how the physical inactivity on Earth can be the cause of increase abdominal fat. Through the usage of a mouse model, Booth ran mice on a wheel for approximately twenty-one days before detraining the mouse from the wheel. The fat pad of the mice was measured after being exercised and after physical in activity. Booth’s research discovered that the mice gained fat from the increase in food intake while experiencing physical inactivity. Booth then exposed his experiment to clinical trials using ten young men. The men were asked to subject themselves to elevators rather than stairs, and drive thru’s rather than walking in. The study produced a theory that a decrease in the number of daily steps showed an increase in body fat, and a decrease in body weight and muscle mass. Also, the amount of oxygen consumed decreases.
The quality of water
Kari Dawson
Dawson’s research was centered around assessing ecological water quality along a creek, ensuring subjective preliminary data. Through the utilization of specific bugs found in the creek, the researcher was able to assess the water quality. Dawson began her research by gathering bugs from five sites of the creek. After collecting a sufficient number of bugs, the bugs were sorted and identified. The bugs provided a relevance to this research in reference to the particular bugs natural endowment to survive in certain quality of water. After identifying the bug, documented research can reveal the bugs sensitivity. In conclusion, Dawson’s research proved the water quality to be exceptional, but not perfect. In an index correlation of her research, Dawson found site two and three to possess the healthiest water.
Impairment of insulin signaling in rat hepatocytes that overexpress glycerol-3-phosphate acetyltransferase -1
Janai Gaston
It is medically claimed that people considered obese are predisposed to type two diabetes or experience insulin resistance. The mechanism for such a relation in the condition, and diseases is primarily declared unknown. This research is used to determine the pathological relationship between glycerolipid synthesis and insulin resistance. The GPAT1 enzyme is known to catalyze the first step to glycerolipid synthesis in primary rat hepatocytes. By infusing a fluorescent protein (EGFP) in the GPAT1 protein, the overexpression of the gene can be examined. GPAT1 overexpression inhibited a transduction molecule in insulin signaling (Akt-S473). This research concluded that an increase flux in glycerolipid synthesis pathway damages insulin signaling transduction, leading to insulin resistance and type 2 diabetes.
Hypertension
Dr. Logan
Logan refers to hypertension at the beginning of his seminar, identifying hypertension as the leading cause of death worldwide. It is statistically known that hypertension is very common amongst African Americans. A person experiences hypertension when their systolic blood pressure exceeds 130 and the diastolic over 90. Approximately 80 million Americans suffer from hypertension, in which the heart muscle must work harder, and the walls grow thicker. Documented hypertension contributes to 80,000 deaths yearly. Individuals who are obese or lack of physical activity can cause high blood pressure. Furthermore, the way a person diets, attaining excessive amounts of salt causes high blood pressure. People may take water pills in order to urinate, causing a decrease in high blood pressure. Based on lifestyle choices it is now common to see young people experiencing high blood pressure. Logan expresses that the increase sympathetic nervous system activity enables the vessels to become narrow. Due to the constricted vessels, cardiac output is increased, signaling hypertension. In addition, angiotensin 2, produce by a peptide, binds to a receptor on the blood vessel, causing narrow vessels. Logan research involved examining NTS in mice medulla portion of the brain. NTS is documented to have relation to hypertension. Barrel receptors in the medulla triggers fluctuations of blood pressure, in which signals the brain, but is blocked during hypertension. Logan assess the kinase regulation pathway to activate AT1 receptors.
Development of Rhodium Catalyzed Carbon-Carbon Bond Formation and Application to the Synthesis of Bisteppogenin
Matthew McGilvary, Dr, Guo
This presentation acquired the analysis of complex heterocyclic molecules, in a natural and unnatural state. This research depicted the relevance of carbon-carbon bond skeletons in complex heterocycles. Through the assessment of carbon-carbon bond formation is vital in assisting the production of heterocycle synthesis. Heterocycle synthesis intimates the formation of complex structures and presents assortment. This ground breaking research generates the innovation of new drugs.